| Date | Location | Result | |
| Oct 30, 2010 | Edwardsville, Pa. | Misericordia 4, Wilkes University 0 | Box score |
| Oct 27, 2010 | Edwardsville, Pa. | LYCOM 4, Wilkes University 0 | Box score |
| Oct 23, 2010 | Edwardsville, Pa. | Wilkes University 1, Manhattanville 0 | Box score |
| Oct 20, 2010 | Wilkes-Barre, Pa. | King's College 4, Wilkes University 0 | Box score |
| Oct 16, 2010 | Madison, NJ | FDU-Florham 1, Wilkes University 0 | Box score |
| Oct 12, 2010 | Edwardsville, Pa. | DeSales 2, Wilkes University 0 | Box score |
| Oct 08, 2010 | St. Davids, Pa. | Eastern University 3, Wilkes University 0 | Box score |
| Oct 06, 2010 | Glenside, PA | ARCADIAM 3, Wilkes University 2 | Box score |
| Oct 04, 2010 | Edwardsville, Pa. | Wilkes University 9, PSUHAZMS 1 | Box score |
| Oct 02, 2010 | Edwardsville, Pa. | Wilkes University 3, Delaware Valley 1 | Box score |
| Sep 25, 2010 | Edwardsville, Pa. | Wilkes University 2, Lebanon Valley 0 | Box score |
| Sep 23, 2010 | Edwardsville, Pa. | Wilkes University 5, Baptist Bible 4 | Box score |
| Sep 18, 2010 | Elizabethtown, PA | Elizabethtown Coll. 6, Wilkes University 1 | Box score |
| Sep 14, 2010 | Edwardsville, Pa. | Dickinson 3, Wilkes University 0 | Box score |
| Sep 12, 2010 | York, Pa. | Medaille 3, Wilkes University 0 | Box score |
| Sep 11, 2010 | York, Pa. | McDaniel 1, Wilkes University 0 | Box score |
| 09/08/10 | Allentown, Pa. | Muhlenberg 4, Wilkes University 0 | Box score |
| Sep 04, 2010 | Aston, Pa. | Neumann University 3, Wilkes University 2 | Box score |
| Sep 01, 2010 | Scranton, PA | Marywood University 3, Wilkes University 2 | Box score |